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Human Psychopharmacology: Clinical and Experimental, 38 (3), e2872

Evening application together is more convenient

But, it has been founded that myeloperoxidase (MPO)-mediated metabolism of PTU led to a reactive metabolite formation which covalently bounded to leukocytes proteins.44 This reactions might be responsible for agranulocytosis as a deleterious adverse effect of PTU.44,45 Many variations in drug metabolizing enzymes in humans has been identified.46 As methimazole is suspected to metabolized to reactive intermediate(s) which might involve in the hepatic injury induced by this drug,36,41 polymorphism in drug metabolizing enzymes might has a role in the idiosyncratic nature of the hepatic injury induced by this antithyroid medication

Given the complexity of the disease, it is therefore not surprising that dissecting cause and effect is not a simple matter

There are a few things, though, that doctors have found could raise the chances of getting it